Prehospital Fibrinolytic Therapy Followed by Urgent Percutaneous Coronary Intervention in Patients with ST-Elevation Myocardial Infarction

Abstract

In patients with ST-segment elevation myocardial infarction (STEMI) the shorter the reperfusion time, the better the outcome is, regardless of the reperfusion method. Effective, early and rapid reperfusion is the most important goal in the treatment of patients with STEMI. In majority cases of STEMI, transport or transfer to a percutaneous coronary intervention (PCI)-capable center will occur, sometimes bypassing the closest hospital facilities that are not PCI centers. The timely optimal reperfusion strategy might be a prehospital initiated pharmacological reperfusion with subsequent PCI. Reduced-dose prehospital fibrinolysis allows safe transport of STEMI patients to PCI centers for urgent culprit artery PCI, and may be a superior approach compared with transporting patients to the closest non-PCI hospital for fibrinolytic therapy. In this review we will discuss the evidence regarding reperfusion strategies in STEMI patients.

Keywords:

• coronary artery disease
• facilated PCI
• fibrinolysis
• myocardial Infarction
• percuataneous coronary intervention

Financial & competing interests disclosure

Ali E Denktas had an unrestricted grant support of moderate amount for the AMICO study. The author has no relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript. This includes employment, consultancies, honoraria, stock ownership or options, expert testimony, grants or patents received or pending, or royalties.

No writing assistance was utilized in the production of this manuscript.

Additional information

Funding

Ali E Denktas had an unrestricted grant support of moderate amount for the AMICO study. The author has no relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript. This includes employment, consultancies, honoraria, stock ownership or options, expert testimony, grants or patents received or pending, or royalties