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Research Article

Subtractive Proteomics to Identify Targets for Vaccine Development Against Vancomycin-Resistant Enterococcus Faecalis

, ORCID Icon, ORCID Icon & ORCID Icon
Pages 1723-1733 | Received 18 Dec 2019, Accepted 23 Nov 2020, Published online: 08 Jan 2021
 

Abstract

Aim: Due to the increased level of vancomycin resistance in Enterococci species, an aggressive treatment involving targeted antibiotics is required to manage this frequently occurring infection. Materials & methods: Here, subtractive proteomics and reverse vaccinology approaches were employed to identify potential target and for the prediction of B cell and T cell epitopes against vancomycin-resistant Enterococcus faecalis (VRE V583). Results: The results exhibited the presence of 73 out of 805 non-homologous protein sequences in the proteome which can be employed as unique targets to develop the novel drugs and vaccine to counter the deadly infections caused by this microbe. Conclusion: The identified novel target in VRE V583 will equip our knowledge to design effective vaccine against probable protease EEP proteins.

Supplementary data

Financial & competing interests disclosure

The authors have no relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript. This includes employment, consultancies, honoraria, stock ownership or options, expert testimony, grants or patents received or pending, or royalties.

No writing assistance was utilized in the production of this manuscript.

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