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Abstract
Evaluation of: Toledo-Arana A, Dussurget O, Nikitas G et al.: The Listeria transcriptional landscape from saprophytism to virulence. Nature 459 (7249), 950–956 (2009). Bacteria adapt to a variety of environmental conditions through changes in gene regulation and gene expression. Listeria monocytogenes is an environmental bacterium that exists as a saprophyte but is capable of transitioning into a pathogen upon ingestion by a susceptible host. In this report, Toledo-Arana et al. present the complete transcriptome of L. monocytogenes and identify a number of novel RNA regulatory elements that may facilitate bacterial adaptation to diverse environments. Their report illustrates a global coordination of transcriptional responses that takes place as the bacterium transitions from life in broth culture to life inside of an infected host.
Financial & competing interests disclosure
The author has no relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript. This includes employment, consultancies, honoraria, stock ownership or options, expert testimony, grants or patents received or pending, or royalties.
No writing assistance was utilized in the production of this manuscript.