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Abstract
Aim: Prognostic differences between major histologic gastric cancer groups, intestinal and diffuse are uncertain, since cellular components in each of them possibly have different behaviors. Materials & methods: We reviewed 198 gastric cancer patients charts diagnosed from January 2003 to December 2015 in a tertiary hospital. Multivariate Cox proportional survival models were used to evaluate the impact of histologic groups on overall survival. Results: About a third had the signet-ring cell carcinoma (SRCC). In a comparison of the different histologic subtypes, SRCC had the worst prognosis of all. The median durations of survival for patients with stage III and stage IV were 19.7 and 7.7 months, respectively. Conclusion: Signet-ring cell component seem to have a relevant role in defining prognosis for gastric cancer.
Supplementary data
To view the supplementary data that accompany this paper please visit the journal website at: www.tandfonline.com/doi/suppl/10.2217/fon-2018-0354
Acknowledgements
The authors gratefully acknowledge the help of statistical support in the Research Support Center (NAP) of Hospital Israelita Albert Einstein.
Financial & competing interests disclosure
The authors have no relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript. This includes employment, consultancies, honoraria, stock ownership or options, expert testimony, grants or patents received or pending, or royalties.
No writing assistance was utilized in the production of this manuscript.
Ethical conduct of research
The authors state that they have obtained appropriate institutional review board approval. The research ethics committee of the institution was consulted on the conduct of the study and approved it in accordance with existing national standards (CAAE: 68438617.5.0000.0071), due to be a retrospective study, an exemption of the consent term was requested.