Incidence and Survival Trends for Appendiceal Mucinous Adenocarcinoma: An Analysis of 3237 Patients in the Surveillance, Epidemiology, and End Results Database

Abstract

Aim: To characterize the epidemiology of appendiceal mucinous adenocarcinoma. Methods: Prognostic factors were evaluated with univariate and multivariate analyses. The results were used to generate a nomogram. Results: The incidence of appendiceal mucinous adenocarcinoma showed a significant upward trend. Multivariate Cox analysis identified 11 independent prognostic factors. The nomogram was based on independent risk factors that were significant in multivariate Cox analysis, and the concordance-index for overall survival and cancer-specific survival were 0.76 (95% CI: 0.71–0.79) and 0.74 (95% CI: 0.70–0.79), respectively. Conclusion: Advanced age, single relationship status, male sex, black race, the presence of distant and regional lymph node metastases, poor differentiation or lack of differentiation, advanced SEER extent of disease, cancer-directed surgery and chemotherapy were independently associated with prognosis.

Keywords::

• appendiceal mucinous adenocarcinoma
• cancer-specific survival
• nomogram
• overall survival
• SEER program

Supplementary data

To view the supplementary data that accompany this paper please visit the journal website at: www.tandfonline.com/doi/suppl/10.2217/fon-2019-0229

Author contributions

Q Yan contributed to the main writing of the article; W Zheng gave guidance on SEER database methods; H Luo did modification and mapping of the article; B Wang and X Zhang carried out revision of the article; S Liu translated the full text; X Wang provided guidance in the whole thesis idea.

Acknowledgments

The authors thank all the patients, investigators and institutions involved in these studies, especially the SEER database.

Financial & competing interests disclosure

The work was supported by Construction of High-Level University in Guangzhou University of Chinese Medicine (grant number: A1-AFD018181A29). The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed.

No writing assistance was utilized in the production of this manuscript.

Ethical conduct of research

Because the patient’s information in the SEER database is not identifiable, the data do not need to be reviewed by an ethics committee, exempting the written informed consent form. However, the authors were allowed to be accessed by the SEER database management department.

Data sharing statement

The datasets used and analyzed during the current study are available from the SEER database (http://seer.cancer.gov/data/sample-dua.html).

Additional information

Funding

The work was supported by Construction of High-Level University in Guangzhou University of Chinese Medicine (grant number: A1-AFD018181A29). The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed. No writing assistance was utilized in the production of this manuscript.