The Effect of Marital Status on Endometrial Cancer-Related Diagnosis and Prognosis: A Surveillance Epidemiology and End Results Database Analysis

Abstract

Aim: Marital status has been proved a significant prognostic factor for diagnosis and prognosis in various cancers, but the effect in endometrial cancer (EMC) is controversial. The research was designed to clarify the relationship between marital status and EMC. Methods: We identified 39,387 patients with EMC between 2004 and 2010 from the Surveillance Epidemiology and End Results database. Patients were categorized into four groups according to marital status. We used the logistic regression, the Kaplan–Meier method and Cox regression analysis to analyze the effect of marital status on EMC-related diagnosis and prognosis. Results: The study suggests that marriage benefits the diagnosis and prognosis of EMC. Widowed and unmarried patients had higher risk of mortality than other marital status.

Keywords::

• endometrial cancer
• marital status
• SEER database
• survival analysis

Author contributions

J Dong had collected the data in the study and takes responsibility for the integrity of the data. J Dong and Q Dai conducted and are responsible for the data analysis. J Dong initiated, planned and designed the conduct of the study. Q Dai conducted data acquisition, management and analysis. J Dong and Q Dai drafted the manuscript. F Zhang wrote and approved the final manuscript. All authors approved the decision to submit the manuscript.

Acknowledgments

I am greatly indebted to my supervisor, F Song, for his valuable instructions and suggestions on my thesis as well as his careful reading of the manuscript. I feel grateful to all the teachers in the Chongqing Medical University who once offered me valuable courses and advice during my study. I sincerely thank D Ruiliang and S Chengrong from whose lectures I benefited greatly. Last but not least, I owe much to my friends and classmates for their valuable suggestions and critiques which are of help and importance in making the thesis a reality.

Financial & competing interests disclosure

This work was supported by the National Undergraduate Innovation and Entrepreneurship Training Program (grant no. 201810631005) and Chongqing Medical University Innovation Experiment Program (grant no. 201703). The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed.

No writing assistance was utilized in the production of this manuscript.

Conflict of interest

The authors declare that they have no conflict of interest.

Additional information

Funding

This work was supported by the National Undergraduate Innovation and Entrepreneurship Training Program (grant no. 201810631005) and Chongqing Medical University Innovation Experiment Program (grant no. 201703). The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed. No writing assistance was utilized in the production of this manuscript.