Evaluation of Platelet Distribution Width as a Diagnostic and Prognostic Biomarker in Bladder Neoplasm

Abstract

Aim: To evaluate the role of preoperative platelet distribution width (PDW) as a potential biomarker for distinguishing malignancy and tumor advantage of bladder neoplasm. Methods: The study included 210 subjects with bladder cancer, 76 subjects with urothelial papilloma and 132 healthy control subjects. Preoperative PDW along with other blood indices was evaluated. Results: PDW was higher in urothelial papilloma patients than that in bladder cancer patients (p < 0.001). Bladder cancer patients with advanced-stage disease exhibited lower PDW levels compared with patients with early stage disease. Conclusion: Reduced preoperative PDW level is an indicator of malignancy and advanced bladder cancer stages, suggesting it as a potential biomarker in bladder cancer diagnosis and prognosis.

Keywords::

• bladder cancer
• platelet distribution width
• TNM stage
• urothelial papilloma

Author contributions

L Liu performed research, analyzed data and wrote the paper; Y Zhao, J Cui, S Chen performed research and analyzed data; B Shi designed and reviewed the work; all authors read and edited the manuscript, and approved the version to be published.

Acknowledgments

The authors thank M Hou and X Liu for assistance in data analysis and guidance in evaluating the significance of platelet indices.

Financial&competing interests disclosure

This work was supported by the Tai Shan Scholar Foundation (to B Shi), Primary Research&Development Plan of Shandong Province (grant 2017GSF18105, grant 2019GSF108123) and National Natural Science Foundation of China (NSFC, no. 81800672). The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed.

No writing assistance was utilized in the production of this manuscript.

Ethical conduct of research

The authors state that they have obtained appropriate institutional review board approval or have followed the principles outlined in the Declaration of Helsinki for all human or animal experimental investigations. In addition, for investigations involving human subjects, informed consent has been obtained from the participants involved.

Data sharing statement

The data analyzed in the study are available from B Shi on reasonable request.

Additional information

Funding

This work was supported by the Tai Shan Scholar Foundation (to B Shi), Primary Research&Development Plan of Shandong Province (grant 2017GSF18105, grant 2019GSF108123) and National Natural Science Foundation of China (NSFC, no. 81800672). The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed. No writing assistance was utilized in the production of this manuscript.