Role of CSF-1 in Progression of Epithelial Ovarian Cancer

Abstract

Despite the dismal outcome seen in the majority of epithelial ovarian cancer patients, there is ongoing progress in understanding the disease at a molecular level. Elucidation of pathways underlying disease progression and metastasis of ovarian cancer is key to development of targeted therapeutics. It is only in this way that therapeutic potential can be translated to reality. Here, we describe the evidence to date for the role of CSF-1/c-fms signaling in ovarian cancer invasiveness and metastasis, including the recent understanding of how CSF-1/c-fms expression is regulated with identification of significant post-transcriptional regulators.

Keywords:

• c-fms proto-oncogene
• CSF-1
• epithelial ovarian cancer
• HuR
• invasion
• metastasis
• post-transcriptional regulation
• urokinase

Financial & competing interests disclosure

Grant support was provided by the NIH grant NIHCA60665. The author has no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed.

No writing assistance was utilized in the production of this manuscript.

Additional information

Funding

Grant support was provided by the NIH grant NIHCA60665. The author has no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed.