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ABSTRACT
Aim: This meta-analysis was conducted to evaluate the diagnostic and prognostic functions of E-cadherin expression in cervical cancer. Methods: PubMed and other databases were searched for articles associated with E-cadherin and cervical cancer. These articles were published before June 2015 and written in English or Chinese. Random-effects model was used to pool odds ratios on the heterogeneity test in the meta-analysis. Results: All of 20 studies were analyzed, in which 522 (42.6%) subjects exhibited reduced E-cadherin expression. Evaluation of clinicopathologic features showed that the downregulation of E-cadherin was related to the overall survival, clinicopathological parameters and age. Conclusion: Downregulation of E-cadherin in cervical cancer patients showed poor overall survival. Therefore, E-cadherinmay be a metastasis-suppressor gene in cervical cancer.
Author contributions
Peng wrote the manuscript. C Liu and F Li provided the content and checked the manuscript for grammar and format. S Qi, P Wang, W Li and L Song helped in collecting and analysis of the data.
Financial & competing interests disclosure
This study was funded by grants from the National Natural Science Foundation of China (81160322 and 81460404) and Shihezi University Initiative Research Projects for Senior Fellows (RCZX201447). The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed.
No writing assistance was utilized in the production of this manuscript.