Predicting and Preventing Viral Escape from Therapy

Abstract

HIV-1 routinely escapes from antiviral drug pressure unless a combination therapy is used. In cases where viral escape follows a reproducible route, one can sometimes use molecular drug-resistance information for improvement of the drug or the therapeutic strategy with the aim to prevent viral escape.

Keywords:

• antiviral drug
• antiviral peptides
• drug design
• drug resistance
• HIV-1
• novel therapy
• RNAi strategies
• virus evolution

Financial & competing interests disclosure

Research in the Berkhout laboratory is supported by the AIDS Fonds (Amsterdam), NWO-Chemical Sciences (Top Grant) and ZonMw (Translational Gene Therapy Program). The author has no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed.

No writing assistance was utilized in the production of this manuscript.

Additional information

Funding

Research in the Berkhout laboratory is supported by the AIDS Fonds (Amsterdam), NWO-Chemical Sciences (Top Grant) and ZonMw (Translational Gene Therapy Program). The author has no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed. No writing assistance was utilized in the production of this manuscript.