The Predictive Value of Liver Tests for the Presence of Liver Metastases

Abstract

Aim

To analyze the predictive value of biochemical liver tests in patients with malignant melanoma, breast, colorectal or lung cancers at the time of diagnosis of liver metastases.

Methods

A retrospective review of patients with the above-mentioned solid tumors at MedStar Georgetown University Hospital from 2016–2020.

Results

The highest optimal cutoff according to sensitivity and specificity for the presence of liver metastases was for AST ≥1.5 × ULN for melanoma, lung, and breast cancers and ≥2 × ULN for colorectal cancer, ALT ≥1.25 × ULN for melanoma, breast and colorectal cancers and ≥1.5 × ULN for lung cancer, and ALP ≥1.5 × ULN for melanoma, breast and colorectal cancers.

Conclusion

Using thresholds of liver enzymes above the ULN may improve the diagnostic accuracy for the presence of liver metastases.

Tweetable abstract

We determined the predictive value of biochemical liver tests in patients with malignant melanoma, breast, colorectal or lung cancers at the time of diagnosis of liver metastases. Read it here now: #openaccess #livercancer.

Keywords::

• breast neoplasms
• colonic neoplasms
• liver biochemical tests
• liver metastases
• lung neoplasms
• malignant melanoma

Author contributions

All authors contributed to the study conception and design. Material preparation, data collection, and analysis were performed by all authors listed. The first draft of the manuscript was written by Alexandra V Kimchy and all authors commented on previous versions of the manuscript. All authors read and approved the final manuscript.

Financial disclosure

The authors have no financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript. This includes employment, consultancies, honoraria, stock ownership or options, expert testimony, grants or patents received or pending, or royalties.

Conflict of interests disclosure

The authors have no competing interests or relevant affiliations with any organization or entity with the subject matter or materials discussed in the manuscript. This includes employment, consultancies, honoraria, stock ownership or options, expert testimony, grants or patents received or pending, or royalties.

Writing disclosure

No writing assistance was utilized in the production of this manuscript.

Ethical conduct of research

The authors state that they have obtained appropriate institutional review board approval or have followed the principles outlined in the Declaration of Helsinki for all human or animal experimental investigations.