Relationship between Vitamin D Receptor Gene Polymorphisms, Cardiovascular Risk Factors and Adiponectin in a Healthy Young Population

Abstract

Aim: To explore the association between VDR polymorphisms and several cardiovascular risk factors and adiponectin. Materials & methods: Three-hundred and sixty-nine healthy students were randomly selected. Five VDR polymorphisms were genotyped: BsmI rs1544410; Cdx2 rs11568820; ApaI rs7975232; TaqI rs731236 and FokI rs2228570. BMI, waist circumference (WC), blood pressure, lipid/glycemic profiles and adiponectin were assessed. Results: In men, BsmI, ApaI and TaqI were associated with BMI and WC (p < 0.05). FokI was associated with triglycerides and high-density lipoprotein levels (p = 0.0036; p = 0.005) whereas BsmI and Cdx2 were associated with adiponectin levels (p = 0.026; p = 0.048). Associations disappeared after BMI and WC adjustments. In women, ApaI was associated with systolic blood pressure (p = 0.02). Conclusion: Our study demonstrated a gender-specific difference between VDR SNPs and various cardiovascular risk factors and adiponectin.

Keywords::

• adiponectin
• cardiovascular risk factors
• healthy subjects
• VDR polymorphism
• vitamin D

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Author contributions

A Hajj participated to the data analysis and was the main author contributing to the manuscript writing. R Chedid performed the sampling of the students. E Chouery and A Megarbané performed the genetic part of the study. M-H Gannagé-Yared designed the study, performed the laboratory analysis, collected the data and participated with A Hajj in the manuscript writing. All the authors approved the final version of the manuscript

Financial & competing interests disclosure

This work was fully funded by a grant from the ‘Conseil de la Recherche de l’Université Saint-Joseph’ (FM213). The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed.

No writing assistance was utilized in the production of this manuscript.

Ethical conduct of research

The authors state that they have obtained appropriate institutional review board approval or have followed the principles outlined in the Declaration of Helsinki for all human or animal experimental investigations. In addition, for investigations involving human subjects, informed consent has been obtained from the participants involved.

Additional information

Funding

This work was fully funded by a grant from the ‘Conseil de la Recherche de l’Université Saint-Joseph’ (FM213). The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed. No writing assistance was utilized in the production of this manuscript.