Pharmacogenetics and the Treatment of Asthma

Abstract

Heterogeneity defines both the natural history of asthma as well as patient’s response to treatment. Pharmacogenomics contribute to understand the genetic basis of drug response and thus to define new therapeutic targets or molecular biomarkers to evaluate treatment effectiveness. This review is initially focused on different genes so far involved in the pharmacological response to asthma treatment. Specific considerations regarding allergic asthma, the pharmacogenetics aspects of polypharmacy and the application of pharmacogenomics in new drugs in asthma will also be addressed. Finally, future perspectives related to epigenetic regulatory elements and the potential impact of systems biology in pharmacogenetics of asthma will be considered.

Keywords::

• allergy
• asthma
• personalized medicine
• pharmacogenomics
• phenotypes

Financial & competing interests disclosure

This work was supported by the Instituto de Salud Carlos III, (PI13/00564 Plan Estatal I+D+i e ISCIII, Subdirección General de Evaluación y Fomento de la Investigación) cofunding with European Regional Development Fund (ERDF) FEDER, by the Junta de Castilla y León (BIO/SA73/15), and by Red Temática de Investigación en Salud Asma, Reacciones Adversas y Alérgicas (RETICS, ARADYAL). Special acknowledgement to the ASIAL (Asociación Salmantina de Inmunoalergia). The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed.

No writing assistance was utilized in the production of this manuscript.

Additional information

Funding

This work was supported by the Instituto de Salud Carlos III, (PI13/00564 Plan Estatal I+D+i e ISCIII, Subdirección General de Evaluación y Fomento de la Investigación) cofunding with European Regional Development Fund (ERDF) FEDER, by the Junta de Castilla y León (BIO/SA73/15), and by Red Temática de Investigación en Salud Asma, Reacciones Adversas y Alérgicas (RETICS, ARADYAL). Special acknowledgement to the ASIAL (Asociación Salmantina de Inmunoalergia). The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed. No writing assistance was utilized in the production of this manuscript.