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Financial & competing interests disclosure
The authors have no relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript. This includes employment, consultancies, honoraria, stock ownership or options, expert testimony, grants or patents received or pending, or royalties.
No writing assistance was utilized in the production of this manuscript.
Disclaimer
The views expressed are those of the author(s) and not necessarily those of the NHS, the individual NHS Trusts or the NIHR or the Department of Health and Social Care. Funding for the project was provided by the NIHR Collaboration for Leadership in Applied Health Research and Care, North West Coast, UK and the Innovation Agency (Academic Health Science Network for the North West Coast). Infrastructure support, inlcuding research nurse support, was provided by the Wolfson Centre for Personalised Medicine and the MRC Centre for Drug Safety Science.