Pharmacogenomics of Cisplatin-Induced Ototoxicity

Abstract

Cisplatin ototoxicity affects different individuals in a widely variable manner. These variations are likely to be explained by genetic differences among those affected. It would be highly advantageous to identify genetic variants that predispose to cisplatin ototoxicity in order to minimize the risk to susceptible subgroups. Although this area of research is very important, only a few studies have rigorously examined the genetic basis for cisplatin-induced susceptibility to hearing loss. This article addresses recent progress in clarifying the incidence of cisplatin ototoxicity and the risk factors and controversies regarding the identification of genetic variants associated with cisplatin-induced hearing loss.

KEYWORDS::

• audiometry
• cisplatin
• COMT
• genome-wide screening
• glutathione
• GST
• GSTM1
• GSTP1
• megalin
• ototoxicity
• pharmacogenomics
• SNP
• TMPT
• XPC

Financial & competing interests disclosure

The authors were supported by the National Institutes of Health (NIH), the National Institute for Deafness and other Communicative Disorders (NIDCD) grants to Debashree Mukherjea (F32-DC 009950) and Leonard P Rybak (R01 DC 02396) during the preparation of this manuscript. The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed.

No writing assistance was utilized in the production of this manuscript.

Additional information

Funding

The authors were supported by the National Institutes of Health (NIH), the National Institute for Deafness and other Communicative Disorders (NIDCD) grants to Debashree Mukherjea (F32-DC 009950) and Leonard P Rybak (R01 DC 02396) during the preparation of this manuscript. The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed. No writing assistance was utilized in the production of this manuscript.