120
Views
0
CrossRef citations to date
0
Altmetric
Case Report

Serotonin Syndrome from Combination Hydrocodone and Cyclobenzaprine in a Patient with Cerebral Palsy

ORCID Icon, , &
Pages 329-334 | Received 13 Apr 2023, Accepted 22 Jun 2023, Published online: 17 Jul 2023
 

Abstract

Aim: Serotonin syndrome (SS) is a life-threatening syndrome that occurs with the use of serotonergic drugs, most commonly due to two or more agents. Cerebral palsy is associated with mood disorders, and more commonly pain, with a prevalence of up to 50–80%. Case presentation: A 58-year-old female with cerebral palsy, metastatic malignancy and mood disorder who presented to the emergency department with acute-on-chronic pain, and signs of SS. She was initiated on iv. dilaudid, titrated off oral medications and scheduled for a left-sided sacroiliac joint injection. Results: It was suspected that due to additional doses of hydrocodone and cyclobenzaprine, she developed moderate-SS. Conclusion: Physicians need to be cognizant of comorbidities and uncommon pain medications that can predispose patients to SS.

Author contributions

V Bansal: contributions meet authorship criteria (a), (b), (c) and (d) as outlined in the Author Disclosure Form. M Aranke: contributions meet authorship criteria (a), (b), (c) and (d) as outlined in the Author Disclosure Form. P Vu: contributions meet authorship criteria (a), (b), (c) and (d) as outlined in the Author Disclosure Form. S Javed: contributions meet authorship criteria (a), (b), (c) and (d) as outlined in the Author Disclosure Form.

Financial & competing interests disclosure

The authors have no relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript. This includes employment, consultancies, honoraria, stock ownership or options, expert testimony, grants or patents received or pending, or royalties.

No writing assistance was utilized in the production of this manuscript.

Informed consent disclosure

The authors state that they have obtained appropriate institutional review board approval for this study protocol. Since this was a retrospectives chart review, a waiver of consent (a waiver of authorization) was obtained due to the retrospective nature of this review, involving no diagnostic or therapeutic intervention and no direct contact with the patients. Obtaining consent from these patients would have been impracticable as they are lost to follow-up, no longer in treatment or deceased.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.