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Abstract
SUMMARY Neuropathic pain (NP) is a disabling condition that may occur following a disease or a lesion of the somatosensory nervous system. With an estimated prevalence of up to 8.2% in the general population, NP is common, and robust and objective diagnostic tools are warranted for pain assessment and follow-up. In the last years research has focused on defining biochemical and histological markers for this purpose, and possible systemic (blood, cerebrospinal fluid) and local (skin and nerve) targets have been investigated in a number of different NP disorders. This article focuses on an update giving an overview over some potential biomarkers for the diagnosis of NP, and will discuss their clinical relevance.
Financial & competing interests disclosure
The authors have no relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript. This includes employment, consultancies, honoraria, stock ownership or options, expert testimony, grants or patents received or pending, or royalties. No writing assistance was utilized in the production of this manuscript.