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ABSTRACT
Prognostic factors of prostate cancer such as PSA, stage, Gleason grade, and surgical margins have limitations; they are inable to indicate metastatic potential. The aim of this study was to investigate expression of e-cadherin, cox-2, p53 and bcl-2 in prostate carcinomas, and to search association with tumor differentiation and metastatic potential.
Eighty-seven prostate cancer specimens were retreived from tissue blocks embedded in parafin, and expression patterns of e-cadherin, cox-2, p53 and bcl-2 were investigated by immunoperoxidase method. Gleason scoring system was used for tumor grading, and expression patterns of these antibodies were compared among different tumor grades.
Seven cases (8%) had well-differentiated, 39 (45%) had moderately differentiated, and 41 (47%) had poorly differentiated tumors. Metastases were present in 31 patients (35%). There was a statistically significant association between tumor differentiation and expression of e-cadherin or bcl-2 (p<0.01); however no association was found between tumor differentiation and expression of cox-2 or p53 (p>0.01). There was no association between expressions of e-cadherin, cox-2, p53 or bcl-2 and metastasis.
E-cadherin expression is less frequent in poorly differentiated tumors; whereas bcl-2 expression is more frequent. However there is no relation with metastatic potential and expression of these markers. Expression of cox-2 and p53 is neither related to the degree of differentiation nor to the metastatic potential.