Abstract
The distribution and fate of 125I-labelled bovine prolactin, human chorionic gonadotropin and bovine serum albumin was studied and followed by serial gamma camera photographs, scintillation counting of blood and tissues, and autoradiography in normal pro-oestrus rats, in oophorectomized rats and in rats with experimental ovarian tumours developed in intrasplenic ovarian grafts after bilateral oophorectomy. A high affinity for 125I-HCG was found both in ovarian tumours and in normal ovaries. An increased active tumour uptake of 125I-HCG was observed for 3 hours, which permitted tumour depicting with gamma-camera technique. The 125I-prolactin uptake was more moderate both in ovaries and ovarian tumours. 125I-albumin showed no specific affinity. The possible application of these findings in diagnosis and therapy of human ovarian tumours is discussed.