Abstract
Treatment of postmenopausal women with a non-steroidal oestrogen (P1496) in a dose of 50 mg a day for 21 days before operation for prolapse did not suppress the histochemically determined fibrinolytic activator content of the vessel wall. Neither was any change found in the concentration of P&P-complex (prothrombin, factor VII, factor X), factor VIII, antithrombin III, α-1antitrypsin, α2-macroglobulin or the inhibitors of urokinase-induced plasminogen activation. Nothing suggested a thrombogenic effect of this non-steroidal oestrogenic compound.