Severe fetal deformities associated with ingestion of excessive isoniazid in early pregnancy

Roger R. Lenke Department of Obstetrics and Gynecology, School of Medicine, University of Washington, Seattle, Washington, 98195; Departments of Obstetrics and Gynecology, Pathology and Pediatrics, University of Southern California School of Medicine, Los Angeles County-University of Southern California Medical Center, Los Angeles, California, USA

Susan Beckwitt Turkel Department of Obstetrics and Gynecology, School of Medicine, University of Washington, Seattle, Washington, 98195; Departments of Obstetrics and Gynecology, Pathology and Pediatrics, University of Southern California School of Medicine, Los Angeles County-University of Southern California Medical Center, Los Angeles, California, USA

Rita Monsen Department of Obstetrics and Gynecology, School of Medicine, University of Washington, Seattle, Washington, 98195; Departments of Obstetrics and Gynecology, Pathology and Pediatrics, University of Southern California School of Medicine, Los Angeles County-University of Southern California Medical Center, Los Angeles, California, USA

Abstract

There is general agreement that pregnant women with active tuberculosis require immediate treatment with some combination of isoniazid (INH), ethambutol, rifampin or streptomycin. Other than the possibility of fetal ototoxicity from streptomycin none of these drugs in normal dosages has proved teratogenous to the human fetus (1). We therefore report here a possible association between fetal malformations and excessive early maternal ingestion of INH.

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Severe fetal deformities associated with ingestion of excessive isoniazid in early pregnancy

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Severe fetal deformities associated with ingestion of excessive isoniazid in early pregnancy

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