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Acta Obstetricia et Gynecologica Scandinavica Volume 65, 1986 - Issue 4
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Original Article

Spironolactone in the Treatment of Hirsutism

M. G. Chapman Institute of Obstetrics and Gynaecology, Chelsea Hospital for Women, London; Guy's Medical School, London; University College Hospital, London, England
,
M. Katz Institute of Obstetrics and Gynaecology, Chelsea Hospital for Women, London; Guy's Medical School, London; University College Hospital, London, England
,
M. Dowsett Institute of Obstetrics and Gynaecology, Chelsea Hospital for Women, London; Guy's Medical School, London; University College Hospital, London, England
,
W. Hague Institute of Obstetrics and Gynaecology, Chelsea Hospital for Women, London; Guy's Medical School, London; University College Hospital, London, England
,
S. L. Jeffcoate Institute of Obstetrics and Gynaecology, Chelsea Hospital for Women, London; Guy's Medical School, London; University College Hospital, London, England
&
C. J. Dewhurst Institute of Obstetrics and Gynaecology, Chelsea Hospital for Women, London; Guy's Medical School, London; University College Hospital, London, England
Pages 349-350 | Received 21 Jun 1984, Accepted 15 Oct 1984, Published online: 03 Aug 2009
 

Abstract

Spironolactone (100 mg) for 25 days in each menstrual cycle was assessed over 6 months for treatment of hirsutism in 35 patients. Five patients withdrew due to either nausea or polymenorrhea. the latter problem was encountered in 16 patients. of the 30 remaining patients, 17 had a significant reduction in hair growth as assessed by Ferriman and Gallwey hair scores (p<0.05). the only significant change in endocrine parameters was a reduction in serum testosterone (p<0.05). Treatment with spironolactone alone was inferior to our previous experience with the cyproterone acetate–estrogen combination.

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