A randomized controlled trial: the efficacy of eluoride rinse combined with calcium pre-rinse to increase overnight salivary fluoride

Abstract

Background. Previous studies have shown that a calcium (Ca) pre-rinse given before a 228 ppm fluoride (F) rinse greatly increased salivary fluoride. Objectives. The aim of this randomized controlled trial is to examine if Ca pre-rinse could increase the fluoride concentration in the overnight unstimulated saliva after a 905 ppm F-rinse. Materials and methods. Pre-rinses containing 150 mM, 75 mM or 0 mM Ca-lactate prepared by a validated pharmaceutical cGPM procedure were tested by nine subjects in a randomized order immediately followed by a 905 ppm F-rinse. The fluoride concentration was measured in unstimulated saliva collected 10 h later. Results and conclusions. The Ca pre-treatment significantly increased F level in overnight saliva following the 905 ppm fluoride rinse by 1.7× relative to the 905 ppm F-rinse alone; however, a significant effect was only observed with the highest (150 mM) Ca concentration as pre-rinse. Clinical relevance. High concentration F rinses (905 ppm) are commonly recommended for patients at high-risk of caries. A pre-treatment with high levels of Ca may further improve the cariostatic effect of this ion.

Key Words::

• calcium
• fluoride
• pre-rinse
• saliva
• RCT

Acknowledgments

Grants from Karolinska Institutet and the Foundation Swedish Patent Revenue Fund for Research in Preventive Odontology are gratefully acknowledged. The funders had no role in study design, data collection and analysis, decision to publish or preparation of the manuscript. Clinical Trial Registration URL: ClinicalTrials.gov Unique identifier: URL: eudract.ema.europe.eu Identifier: 2011-001885-16.

Declaration of interest: The authors report no conflicts of interest. The authors alone are responsible for the content and writing of the paper.