Evaluation of internal consistency of the epidermolysis bullosa oropharyngeal severity score (EBOS)

Abstract

Objective. To evaluate the internal consistency of the epidermolysis bullosa oropharyngeal severity score (EBOS). Materials and methods. Data from 92 patients of varying EB types/sub-types already described in a previous multi-center study were re-analyzed via the coefficient Cronbach’s α (CR-α). Additionally, the corrected item total correlation between each item and the items’ overall score with Pearson’s product-moment correlation (ρ) was calculated. Results. The alpha coefficient for the mean total score of 17 items is 0.941. The inter-observer reliability for disease severity score was excellent for oral medicine specialist (α = 0.924) and dermatologist (α = 0.916) and the intra-observer reliability was good at Time 1 (α = 0.895) and Time 2 (α = 0.897). The analysis of CR-α per single item revealed that alpha was greater than 0.904 for disease activity and 0.743 for structural damage, after the elimination of four items for oral medicine specialist and greater than 0.898 for disease activity and 0.769 for structural damage after the elimination of five items for dermatologist. Similarly the analysis of the corrected items-EBOS correlation showed that the same items do not correlate very well (ρ < 0.4) with the overall EBOS. Conclusions. The EBOS turned out to have a strong and reliable internal consistency, as the majority of the EBOS’ items were consistent with each other.

Key Words:

• EB
• consistency
• score
• validity
• reliability

Declaration of interest: The authors report no conflicts of interest. Contents of the manuscript have not been previously published or presented in a congress and are not currently submitted elsewhere.