The effect of tetracyclines on socket healing

Abstract

An investigation was made of the effect of tetracycline on socket healing when used as bone marker. The material consisted of 52 white rats, on which the first molars were extracted.

The rats were divided in experimental groups given tetracycline in doses of 1 × 30 mg, 3 × 30 mg, 1 × 120 mg and 3 × 120 mg, respectively, and in a control group. Histologic comparison of socket healing between the experimental animals and their controls after 4, 8 and 16 days, showed only small differences between the parameters studied. The differences were, however, not statistically significant.

The results of the investigation thus show that tetracyclines, administered in doses as here, can be used as bone marker for studies of socket healing in rats without untoward effects on the healing procedure.

Key Words:

• Healing
• tetracycline