Sensitization of guinea pigs with chlorhexidine

Abstract

Guinea pigs were immunized with autologous serum exposed to chlorhexidine gluconate. Injections were given every second day for one week. After four weeks the animals were given a booster-dose and were tested for antibodies using the cutaneous anaphylaxis test. The titre of chlorhexidine-treated serum showing a positive reaction was 1: 1000 in immunized animals. Control animals showed positive reaction in a dilution of 1: 10 but negative in 1: 100.

Key Words:

• Chlorhexidine
• immunology
• animal studies