β-lumicolchicine as a Tool to Elucidate Microtubular Function in Dentinogenesis

Jon Einar Dahl Department of Pathology, Dental Faculty, University of Oslo, Oslo, Norway

Torbjørn Stene Department of Pathology, Dental Faculty, University of Oslo, Oslo, Norway

Hanna Strømme Koppang Department of Pathology, Dental Faculty, University of Oslo, Oslo, Norway

Rolf Koppang Department of Dental Technology, Dental Faculty, University of Oslo, Oslo, Norway

Torvald Stokke Department of Pathology, Dental Faculty, University of Oslo, Oslo, Norway

Abstract

β-lumicolchicine, an isomer of colchicine which does not interrupt microtubular function, was given to 8 rats in a dose of 1.5 mg/kg. Four rats served as controls. Histomorphological investigations of odontoblasts and dentin in the maxillary incisors after two weeks revealed no disturbances. This finding, compared with the previously reported effects of colchicine, as well as colcemid, vincristine and vinblastine, indicates dentin production to be dependant on microtubules.

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β-lumicolchicine as a Tool to Elucidate Microtubular Function in Dentinogenesis

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β-lumicolchicine as a Tool to Elucidate Microtubular Function in Dentinogenesis

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