In situ characterization of mononuclear cells in marginal periodontitis of patients with Down's syndrome

Per David Clee Søhoel Department of Periodontology, Laboratory for Oral Microbiology, School of Dentistry, University of Bergen, and Vestlandsheimen, Bergen, Norway; Department of Oral Pathology and Forensic Odontology, School of Dentistry, University of Bergen, and Vestlandsheimen, Bergen, Norway

Anne Christine Johannessen Department of Periodontology, Laboratory for Oral Microbiology, School of Dentistry, University of Bergen, and Vestlandsheimen, Bergen, Norway; Department of Oral Pathology and Forensic Odontology, School of Dentistry, University of Bergen, and Vestlandsheimen, Bergen, Norway

Tore Kristoffersen Department of Periodontology, Laboratory for Oral Microbiology, School of Dentistry, University of Bergen, and Vestlandsheimen, Bergen, Norway; Department of Oral Pathology and Forensic Odontology, School of Dentistry, University of Bergen, and Vestlandsheimen, Bergen, Norway

Yngve Haugstvedt Department of Periodontology, Laboratory for Oral Microbiology, School of Dentistry, University of Bergen, and Vestlandsheimen, Bergen, Norway; Department of Oral Pathology and Forensic Odontology, School of Dentistry, University of Bergen, and Vestlandsheimen, Bergen, Norway

Rune Nilsen Department of Periodontology, Laboratory for Oral Microbiology, School of Dentistry, University of Bergen, and Vestlandsheimen, Bergen, Norway; Department of Oral Pathology and Forensic Odontology, School of Dentistry, University of Bergen, and Vestlandsheimen, Bergen, Norway

Abstract

An indirect immunofluorescence technique on cryostat sections was used to study the cellular composition in chronic marginal periodontitis (CMP) of patients with Down's syndrome (DS). The findings were compared with CMP lesions in otherwise normal patients (NP). The distribution and amount of CD22⁺ cells (B IymphoLytes), CD3⁺ cells (pan T lymphocytes), CD4⁺ cells (helper T subset), CD8⁺ cells (suppressor/cytotoxic T subset), and CD11c⁺ cells (in tissue, mainly monocytes and macrophages) were investigated. Morphologic studies showed a denser inflammatory infiltrate in DS than in NP. Counting showed significant differences in cell distribution (p = 0.0003) and cell profiles (p = 0.0273) between the two groups. The median CD4⁺/CD8⁺ ratio in DS (2.73) was significantly higher (p = 0.0024) than found in gingival inflammatory lesions from NP (1.08). The present study shows that DS patients have a different, more pronounced, immune response in CMP than NP. □ Inflammntion; periodontal diseases; trisomy 21

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In situ characterization of mononuclear cells in marginal periodontitis of patients with Down's syndrome

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In situ characterization of mononuclear cells in marginal periodontitis of patients with Down's syndrome

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