Prostaglandin E₂ Level in Gingival Crevicular Fluid from Patients with Down Syndrome

Abstract

Barr-Agholme M, Krehanova L, Yucel-Lindberg T, Shinoda K, Modéer T. Prostaglandin E₂ level in gingival crevicular fluid from patients with Down syndrome.

The levels of prostaglandin E₂ (PGE₂) and interleukin-1β (IL-1β) were determined in gingival crevicular fluid (GCF) collected &om patients with gingivitis: 15 Dog syndrome children and 15 controls. The mean level of PGE₂ in GCF was significantly higher (P <0.05) in the Down syndrome group (10.0 pg/μl GCF) than in the control group (4.6 pg/μl GCF). In GCF samples collected from sites characterized as noninflamed, the mean level of PGE₂ was significantly higher (P < 0.001) in the Down syndrome group than in the controls. The mean level of PGE₂ in samples from inflamed sites, on the other hand, did not differ between the two groups. The mean level of IL-1β was not significantly higher in the Down syndrome group than in the controls. This study shows that the level of PGEl detected in GCF &om Down syndrome patients is increased, a fact that may be of importance in the pathogenesis of the periodontal disease frequently seen in these patients.

Key Words:

• Children
• gingivitis
• interleukin-1β
• periodontal disease