Weekly paclitaxel for platin-resistant stage IV head and neck cancer patients

Abstract

Conclusions. Weekly paclitaxel may be an active and well tolerated chemotherapy regimen for patients with platin-resistant advanced head and neck cancer. Objectives. Weekly paclitaxel should be an active and well tolerated regimen for palliative treatment of platin-resistant patients with recurrent or metastatic carcinoma of the head and neck. We analyzed the antitumor activity and toxicity profile. Patients and methods. Sixty consecutive patients with advanced head and neck cancer were treated with 1 h infusion of paclitaxel, 80 mg/m² weekly, for 6 consecutive weeks. Patients who showed disease response or disease stabilization continued until progression of disease. Results. A total of 719 doses of paclitaxel were administered to the 60 patients. No complete response was observed. Partial response and stable disease were observed in 26 (43.3%) and 9 (15%) patients, respectively. Median time to tumor progression for patients who responded to therapy was 6.2 months (SD=1.3; 95% CI, 3.7–8.6) and the overall median survival in this group of patients was 8.5 months (SD=1.4; 95% CI, 5.7–11.2). The main toxic effects were leukopenia (26.6%), anemia (43.3%), fatigue (37.4%), alopecia (18.7%), rash/desquamation (13.3%), and thrombophlebitis (6.8%).

• Advanced tumors
• head and neck cancer
• squamous cell carcinoma
• chemotherapy