Diagnostic Applications of Radiophosphorus for Malignant Neoplasms in Otorhinolaryngology

Abstract

The author made a fundamental and clinical investigation to utilize radiophosphorus P³² as a diagnostic indicator for malignant neoplasms in otorhinolaryngology. In the preliminary study phosphorus distribution in normal and cancerous tissues was observed by measuring their radioactivity. The majority of the tissues bearing malignant neoplasms absorbed radiophosphorus much more abundantly than the other normal tissues of the same patient. For the purpose of clinical application of P³² the author administered intravenously P³² saline solution to 78 in-patients and then placed Anton's Miniature Counter Tubes in contact with the skin surface and inserted them directly into the body cavity of the subjects. The radioactivity of the involved area and the corresponding normal area was measured and compared at 1, 3 and 6 hours following P³² administration. The author concluded that a mean concentration ratio beyond 130 per cent could signify the existence of malignant neoplasm.