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Abstract
A case of juvenile nasopharyngeal angiofibroma treated preoperative first with androgen and then with estrogen is reported. Under androgen therapy the tumor appeared to enlarge somewhat. This was followed by a course of estrogen therapy which resulted in a prompt and dramatic involution and decrease in size of the tumor. It became very firm and permitted evulsion with a minimal ((600 cc) blood loss for this type of tumor. The response of this tumor to estrogen was similar to that found by one of the authors in four previously unreported cases. Microscopic pictures showed a dramatic fibrosis with maturation of the vascular and connective tissue elements. Preoperative estrogen therapy is recommended as a supplement but not a substitute for surgery. The blood loss is definitely decreased.