Experimental Transfer of Allergic Information in Laboratory Animals

Abstract

In three series of experiments on guinea pigs the authors have transferred sensitization to ovalbumin from sensitized animals to normal animals by means of a temporary skin graft which was explanted after staying in the recipient for 7 days. In the same way desensitization could also be transferred as an immunological information to sensitized animals. The authors conclude that sensitization and desensitization are coded and memorized in cell elements and can be transferred to a homologous animal in the shape of a molecular graft which becomes incorporated into the genetic system of immunologically competent cells.