The Vestibular Effects of Meclizine Hydrochloride-Niacin Combination (Antivert)

Abstract

Objective, electronystagmography monitored positional, caloric, rotational or linear acceleration vestibular tests were carried out on 30 normal subjects and 30 subjects with vestibular disease before and after administration with meclizine hydrochloride-niacin combination or placebo. The authors found the otolithic and semicircular canal functions to be most effected. Side effects were few and minor. This drug seems very useful for treatment of ambulatory patients with vestibular disease. The effect on vestibular function of normal individuals was noted only during linear acceleration.