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Abstract
In this study a preliminary report is given of enzymatic studies of the perilymph from otosclerotic patients. Two methods were used. Firstly an enzymatic dissolution of a gelatin film coating was used as a screening method. This method showed hydrolytic activity in 75% and a remarkably close correlation to the evolution of the perceptive hearing loss. Secondly, to identify the different enzymes, Uriel & Avrameas' micro-electrophoretic method was used, and a high activity of especially acid phosphatase, collagenase and chymotrypsin was demonstrated. In this study there was also a striking correlation of hydrolytic activity to the development of the perceptive hearing loss. It is suggested that these enzymes play a major role in the progressive inner ear disease in otosclerosis.