Studies of Ldh Activity Concerning Malignant Transformation from Chronic Sinusitis

Abstract

The LDH activity of maxillary cancer tissues was considerably higher than in the other tissues including the surrounding tissues, irradiated cancer tissues, and the mucosa of the maxillary sinus in chronic sinusitis. from the standpoint of classified LDH isozyme patterns, the maxillary cancer tissues were characterized by predominant fractions of LDH₄ and LDHs in contrast to the chronic sinusitis tissues in which LDHa prevailed. We designated the type of the former “Cancer type” and the latter, “Inflammation type”, and proposed designation of ten types of the LDH isoenzyme pattern (from 1 to 10). the enzymologic studies on the basis of the LDH activity and isozyme aspect classified that the histologically proliferative type in chronic sinusitis resembles the cancer type.