Ethacrynic Acid-Induced Hearing Loss in Guinea Pigs

Abstract

In normal guinea pigs Ethacrynic acid was shown to cause a reversible high-tone hearing loss with evidence of recruitment. There was a definite tendency to a dose-response relationship. The unchanged Preyer reflex level, in animals with even marked elevations of the hearing threshold, demonstrated the impossibility of evaluating hearing function by Preyer reflex determinations only. Kanamy-cin-treated animals demonstrated unimpaired ability to respond to Ethacrynic acid as above.