Sensitization And Local Application Of Antibiotics On The Respiratory Mucous Membrane

Z. Krajina Departments of Otolaryngology, Dermatology and Pediatrics, the School of Public Health, Vniversit.v of Zagreb, Zagreb, Yugoslavia

A. Brnobié Departments of Otolaryngology, Dermatology and Pediatrics, the School of Public Health, Vniversit.v of Zagreb, Zagreb, Yugoslavia

V. Konié-carnelutti Departments of Otolaryngology, Dermatology and Pediatrics, the School of Public Health, Vniversit.v of Zagreb, Zagreb, Yugoslavia

Zˆ. Poljak Departments of Otolaryngology, Dermatology and Pediatrics, the School of Public Health, Vniversit.v of Zagreb, Zagreb, Yugoslavia

Zˆ. Zˆagar Departments of Otolaryngology, Dermatology and Pediatrics, the School of Public Health, Vniversit.v of Zagreb, Zagreb, Yugoslavia

Abstract

Local application of antibiotics to the respiratory mucous membrane in the form of drops and aerosol is more and more often used. Here the question arises of sensitization of the mucosa to the penicillin, being the strongest allergenic remedy. Experimentally, we tried with aerosol to provoke the sensitization in rabbits and we observed patients who had received aerosol several times. Laboratory examinations were made in the form of basophil degranulation determinations and compared with the control group. The results are discussed.

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