Abstract
As part of a programme to improve the operative results in surgery for congenital meatal atresia, we have studied the fate of freeze-dried homograft bone in dogs when implanted as an isotopic graft. Histological studies were made of the graft reaction at regular intervals up to 2 years. Osteogenic activity was monitored by tetracycline fluoroscopy. Regional lymph nodes were examined for evidence of graft rejection. There was no homograft reaction and the graft acted as a scaffold for new bone formation.