The Patas Monkey as a Model for Dihydrostreptomycin Ototoxicity

J. E. Hawkins Kresge Hearing Research Institute and the Department of Otorhinolaryngology, University of Michigan Medical School, Ann Arbor, Mi, USA

W. C. Stebbins Kresge Hearing Research Institute and the Department of Otorhinolaryngology, University of Michigan Medical School, Ann Arbor, Mi, USA

L.-G. Johnsson Kresge Hearing Research Institute and the Department of Otorhinolaryngology, University of Michigan Medical School, Ann Arbor, Mi, USA

D. B. Moody Kresge Hearing Research Institute and the Department of Otorhinolaryngology, University of Michigan Medical School, Ann Arbor, Mi, USA

A. Muraski Kresge Hearing Research Institute and the Department of Otorhinolaryngology, University of Michigan Medical School, Ann Arbor, Mi, USA

Abstract

Although the cochlear toxicity of dihydro-streptomycin (DHSM) is well-recognized in man, it has always proved difficult to demonstrate in animals. Hearing thresholds in M. nemestrina monkeys remained essentially unchanged after DHSM 100 mg/kg im daily for 8 months, but E. patas monkeys were severely deafened by DHSM 20 mg/kg for 90 days, a regimen formerly used in treating human tuberculosis. The patas monkey may prove to be the animal model of choice for evaluating aminoglycoside ototoxicity.

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The Patas Monkey as a Model for Dihydrostreptomycin Ototoxicity

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The Patas Monkey as a Model for Dihydrostreptomycin Ototoxicity

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