Active Phenoxymethylpenicillin (Pcv) in the Mucous Membranes of the Oral Bucca and Maxillary Sinus and in Diffusion Chambers Implanted in Rabbits: A Methodological Study

Abstract

The intention of prescribing antibiotic treatment must be to achieve a concentration of the agent within the infected tissue well above the MIC for the bacteria causing the infection. As a basis for further clinical studies on antibiotic concentrations in maxillary sinus mucosa in humans, determinations of biologically active penicillin V in the mucous membranes of the maxillary sinus and the buccal mucosa as well as in tissue fluids and tissue from subcutaneously implanted tissue cages in rabbits were made. Several experimental conditions were studied, with the purpose of establishing optimal conditions with regard to tissue sampling, blood contamination, prediffusion time, etc. Penicillin V was shown to have a good penetration into mucosal tissue in the rabbit. even at low perfusion pressure.