10
Views
44
CrossRef citations to date
0
Altmetric
Original Article

The Human Acoustic Neurinoma in Organ Culture

, &
Pages 223-235 | Received 19 Mar 1980, Published online: 08 Jul 2009
 

Abstract

Acoustic neurinoma tissue in organ culture was exposed to gamma irradiation (60CO) 30-150 Gy single dose. Schwann cell degeneration occured from the first week onward in vitro following irradiation. After 3 weeks only a limited number of surviving cells were observed in the specimens, as compared with controls. the in vitro changes in tissue morphology indicate an irreversible course even after irradiation with the lowest dose, 30 Gy single dose. As a comparison with the in vitro experimental material it has also been possible to analyse the light and electron microscopic morphology of a tumour from a patient previously treated with stereotactic radiosurgery. An similar substantial Schwann cell loss was found in the centre of the tumour treated with stereotactic irradiation prior to surgery, as compared with the in vitro material.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.