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Acta Oto-Laryngologica Volume 91, 1981 - Issue 1-6
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Original Article

Otic Placode and Cephalic Neural Crest

C. D. A. Verwoerd Department of Otohinolaryngology, University of Amsterdam, The Netherlands
,
C. G. Van Oostrom Department of Anatomy and Embryology, University of Amsterdam, The Netherlands
&
H. L. Verwoerd-Verhoef Department of Paediatrics, University of Nijmegen, The Netherlands
Pages 431-435 | Published online: 08 Jul 2009
 
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Abstract

The otic placode does not develop by local thickening of the ectoderm; it gradually becomes distinct as the surrounding ectoderm thins. This thinning in the 5-8 somite stage can be explained by the observation of many ectodermal cells breaking away from the superficial ectoderm and changing into ectodermal mesenchyme (neural crest).

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