Vestibular Nuclear Neuron Activity in Chronically Hemilabyrinthectomized Cats

Abstract

The activity of central vestibular neurons (V_n) of the horizontal canal system was recorded in chronically hemilabyrinthectomized cats and compared with that of labyrinth intact animals. In both groups the cerebellar vermis was removed in order to assess the efficacy of the vestibular brainstem commissure alone by means of polarizing currents applied to the labyrinths. Experiments were carried out under Ketamine anaesthesia. In control animals the mean resting rates of type I and type II V_n measured 22.4±14.0 and 27.5±14.6 imp/s respectively, and the type I responses occurred ca. 3x more frequently than type II. In the lesioned animals a drastic reduction of the number of type I responses was found on the deafferented side, while that on the intact side remained normal. The resting rates of type I V_n on the two sides did not differ significantly from each other but were significantly lower than those of control animals. In contrast, type II responses were present on the deafferented side, but almost completely missing on the intact side. Applying polarizing stimuli in control animals, it was found that both labyrinths have similar weight in driving V_n. In lesioned animals, no major changes in the efficacy of the commissural path were found when polarizing stimuli were applied to the intact side. It is concluded that vestibular nerve section causes a severe loss of type I responses in the vestibular nuclei on the side of the lesion which apparently is not compensated by an adaptive change in the commissural path and, therefore, may be mainly responsible for the VOR asymmetry observed concomitantly.