Spindle Cell Carcinoma of the Larynx

Morten Katholm ENT Department, Gentofte University Hospital, Copenhagen, Denmark; Departments of Pathology, Gentofte University Hospital and Herlev University Hospital, Copenhagen, Denmark

Annelise Krogdahl ENT Department, Gentofte University Hospital, Copenhagen, Denmark; Departments of Pathology, Gentofte University Hospital and Herlev University Hospital, Copenhagen, Denmark

Bo Hainau ENT Department, Gentofte University Hospital, Copenhagen, Denmark; Departments of Pathology, Gentofte University Hospital and Herlev University Hospital, Copenhagen, Denmark

Poul Bretlau ENT Department, Gentofte University Hospital, Copenhagen, Denmark; Departments of Pathology, Gentofte University Hospital and Herlev University Hospital, Copenhagen, Denmark

Abstract

Histology, histogenesis, biology and treatment of the rare spindle cell carcinoma of the larynx are presented. The histogenesis of spindle cell tumours has been much debated, but electron microscopic investigations have shown that most of the laryngeal lesions are squamous epithelial carcinomas that have undergone transformation to a spindle cell pattern. As confusion with supporting tissue neoplasms may occur in the light microscope, the use of the electron microscope in differential diagnostics is recommended.

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Related Research Data

How phenotype guides management of non-conventional squamous cell carcinomas of the larynx?

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