Virus-induced Central Positional Nystagmus in Mice

Abstract

Geotropic direction-changing nystagmus in lateral body positions was observed in 4-week-old BALB/c mice after intracerebral injection with a temperature-sensitive mutant of mouse hepatitis virus. The positional nystagmus was detected already 2 days after infection and it lasted half a year at least. The nystagmic responses of the semicircular canals were also evaluated before and after infection. They were unaltered during the disease, which was clinically manifested by general weakness, ataxia and tremor. Histopathological examination 2 weeks after infection revealed demyelination in various parts of the CNS.

Key Words:

• mouse hepatitis virus (strain A59)
• virus-induced demyelination
• vestibuloocular reflex (VOR)
• time constant of VOR