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Acta Oto-Laryngologica Volume 100, 1985 - Issue 1-2
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Original Article

Bone Resorption in Chronic Otitis Media the Role of Mast Cells

Gilead Berger St. Joseph's Health Centre and the Department of Otolaryngology, University of Toronto, Canada
,
Michael Hawke Temporal Bone Histopathology Laboratory, Department of Otolaryngology, University of Toronto, Canada
&
J. Kenneth Ekem Charlie Conacher Research Laboratory, Department of Otolaryngology, Queen Elizabeth Hospital, University of Toronto, Canada
Pages 72-80 | Published online: 08 Jul 2009
 
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Abstract

Twenty-two surgical specimens of eroded middle ear ossicles were removed from patients with chronic otitis media, with and without cholesteatoma. By using specific mast cell stains, increased numbers of mast cells were found in connective or granulation tissue adjacent to eroded surface of the bone. Mast cells possess the biological machinery necessary for enhancing bone resorption, and the population density of mast cells is increased in a variety of disorders that are associated with bone resorption. It is hypothesized that mast cells contribute to bone resorption in chronic otitis media, and the possible mechanisms by which mast cells exert their action are discussed.

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