A Model for in Vitro Growth of Human Oral Carcinomas. A Preliminary Report

Arne Jepsen Dept. Oral Medicine and Diagnosis, Royal Dental College, Vennelyst Boulevard, DK-8000, Aarhus C, Denmark

Dorthe Arenholt-Bindslev Dept. Oral Medicine and Diagnosis, Royal Dental College, Vennelyst Boulevard, DK-8000, Aarhus C, Denmark

Troels Bundgaard Dept. Otolaryngology, University Hospital, DK-8000, Aarhus C, Denmark

Hans Peter Philipsen Dept. Oral Medicine and Diagnosis, Royal Dental College, Vennelyst Boulevard, DK-8000, Aarhus C, Denmark

John Wildt Dept. Otolaryngology, University Hospital, DK-8000, Aarhus C, Denmark

Poul Bjerrum Dept. Otolaryngology, University Hospital, DK-8000, Aarhus C, Denmark

Ole Elbrønd Dept. Otolaryngology, University Hospital, DK-8000, Aarhus C, Denmark

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Abstract

Tumour tissue and normal human oral epithelium from 9 cases of intra-oral carcinoma were established as explant cultures.

Outgrowth was obtained from 7 cases and 2 failed to grow in vitro. Cytomorphologically heterogeneous outgrowths were observed in 5 cases, whereas in 2 cases morphologically uniform cells grew out from the explants. Tumour cells were kept proliferating for more than 3 months enabling long term studies of the biological characteristics of tumour cells from human intra-oral carcinomas.

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A Model for in Vitro Growth of Human Oral Carcinomas. A Preliminary Report

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A Model for in Vitro Growth of Human Oral Carcinomas. A Preliminary Report

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