Experimental Labyrinthitis in Rats Caused by Infecting with Virus Causing Hemorrhagic Fever with Renal Syndrome (HFRS)

M. Tamura Department of Otolaryngology, Osaka University Medical School, Osaka, Japan

S. Ogino Department of Otolaryngology, Osaka University Medical School, Osaka, Japan

T. Matsunaga Department of Otolaryngology, Osaka University Medical School, Osaka, Japan

H. Asada Department of Virology, Research Institute for Microbial Diseases, Osaka University, Osaka, Japan

K. Kondo Department of Virology, Research Institute for Microbial Diseases, Osaka University, Osaka, Japan

K. Yamanishi Department of Virology, Research Institute for Microbial Diseases, Osaka University, Osaka, Japan

T. Kurata Department of Pathology, National Institute of Health, Tokyo, Japan

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Abstract

Acute and persistent viral infection of the inner ear of rats was induced with hemorrhagic fever with renal syndrome (HFRS) virus following intraperitoneal inoculation. Newborn (within 24 h after birth) rats were inoculated intraperitoneally (i.p.) with HFRS virus (B-1 strain), and the cochlea was examined using an immunohistochemical technique for the localization of viral antigens 1 week (acute infection) and 1 year (persistent infection) after infection. Virus-specific antigens were detected in the inner ear structures of the rats suffering from both acute and persistent infection. Morphological changes in the inner ear structures of these rats were observed, with hemorrhage and infiltration of lymphocytes and macrophages. Moreover virus could be isolated from the blood of all infected rats. In the present study, we have proved that HFRS virus can infect the inner ear via the viremia.

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Experimental Labyrinthitis in Rats Caused by Infecting with Virus Causing Hemorrhagic Fever with Renal Syndrome (HFRS)

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Experimental Labyrinthitis in Rats Caused by Infecting with Virus Causing Hemorrhagic Fever with Renal Syndrome (HFRS)

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