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Abstract
Conclusions This study shows that the prevalence of auditory neuropathy spectrum disorder (ANSD) in the children with inner auditory canal (IAC) stenosis is much higher than those without IAC stenosis, regardless of whether they have other inner ear anomalies. In addition, the auditory characteristics of ANSD with IAC stenosis are significantly different from those of ANSD without any middle and inner ear malformations. Objectives To describe the auditory characteristics in children with IAC stenosis as well as to examine whether the narrow inner auditory canal is associated with ANSD. Method A total of 21 children, with inner auditory canal stenosis, participated in this study. A series of auditory tests were measured. Meanwhile, a comparative study was conducted on the auditory characteristics of ANSD, based on whether the children were associated with isolated IAC stenosis. Results Wave V in the ABR was not observed in all the patients, while cochlear microphonic (CM) response was detected in 81.1% ears with stenotic IAC. Sixteen of 19 (84.2%) ears with isolated IAC stenosis had CM response present on auditory brainstem responses (ABR) waveforms. There was no significant difference in ANSD characteristics between the children with and without isolated IAC stenosis.
Acknowledgements
We are grateful to the radiologists and patients for their support. Dr Honglu Shi deserves our gratitude for his advice on data analysis.
Disclosure statement
The authors report no conflicts of interest. This work is supported by National Natural Science Foundation of China(81100711), Youth fund project of Shandong provincial medical technology development plan (2011WSB02002), Natural science Foundation of Shandong province (No.ZR2010HM001), The research special fund for public welfare industry of health ?201202001), Foundation for Excellent Young and Middle-Aged Scientists ofShandong Province (No. BS2012YY028).